| National Humanities Center | European and American Young Scholars' Summer Institutes | 03/19/10 | $485,000 | Research Triangle Park, NC, United States | Higher Learning |
| University of Chicago | Distinguished Achievement Award [Lear] | 03/19/10 | $1,500,000 | Chicago, IL, United States | Higher Learning |
| Duke University | New Directions Fellowships [Dubois] | 03/19/10 | $321,000 | Durham, NC, United States | Higher Learning |
| University of Toronto | New Directions Fellowships | 03/19/10 | $274,000 | Toronto, Ontario, Canada | Higher Learning |
| Gallaudet University | Gallaudet Deaf Digital Library | 03/19/10 | $500,000 | Washington, DC, United States | Higher Learning |
| Amherst College | Faculty-Student Research | 03/19/10 | $200,000 | Amherst, MA, United States | Higher Learning |
| Berea College | Senior President: Reshaping the Academic Structure | 03/19/10 | $250,000 | Berea, KY, United States | Higher Learning |
| Hendrix College | Mid-Career President: Curricular Initiatives | 03/19/10 | $150,000 | Conway, AR, United States | Higher Learning |
| Queens College | Mellon Mays Undergraduate Fellowship Program - Additional Years Support | 03/19/10 | $123,800 | Flushing, NY, United States | Higher Learning |
| Washington University in St. Louis | Mellon Mays Undergraduate Fellowship Program - Additional Years Support | 03/19/10 | $123,800 | St. Louis, MO, United States | Higher Learning |
| University of California at Los Angeles | Mellon Mays Undergraduate Fellowship Program - 10% Increase | 03/19/10 | $22,500 | Los Angeles, CA, United States | Higher Learning |
| University of Cape Town | MA & PhD Fellowships | 03/19/10 | $800,000 | Cape Town, South Africa | International Higher Education and Strategic Projects |
| University of the Witwatersrand | Postdoctoral Fellowships | 03/19/10 | $350,000 | Johannesburg, South Africa | International Higher Education and Strategic Projects |
| Virginia Foundation for the Humanities and Public Policy | Developing an Online Prosopographical Database of the Founding Era II | 03/19/10 | $660,000 | Charlottesville, VA, United States | Public Knowledge |
| Misnomer Inc. | Audience Engagement Platform Development | 03/19/10 | $200,000 | Brooklyn, NY, United States | Arts and Culture |
| Solomon R. Guggenheim Foundation | Panza Collection Initiative | 03/19/10 | $1,230,000 | New York, NY, United States | Arts and Culture |
| Los Angeles Opera Company | National Radio Broadcasts | 03/19/10 | $600,000 | Los Angeles, CA, United States | Arts and Culture |
| Mid Atlantic Arts Foundation, Inc. | Travel Grant Program for US Performance Ensembles | 03/19/10 | $700,000 | Baltimore, MD, United States | Arts and Culture |
| Wageningen University, Department of Plant Sciences | Plants Initiative | 03/19/10 | $607,000 | Wageningen, The Netherlands | Past Programs |
| Swedish Museum of Natural History | Plants Initiative | 03/19/10 | $187,000 | Stockholm, Sweden | Past Programs |
| M.G. Kholodny Institute of Botany of the National Academy of Sciences of Ukraine | Plants Initiative | 03/19/10 | $64,000 | Kiev, Ukraine | Past Programs |
| National Humanities Center | Fellowships | 03/19/10 | $700,000 | Research Triangle Park, NC, United States | Higher Learning |
| Northwestern University | Distinguished Achievement Award [Muir] | 03/19/10 | $1,500,000 | Evanston, IL, United States | Higher Learning |
| Davidson College | New Directions Fellowships [Lozada] | 03/19/10 | $252,000 | Davidson, NC, United States | Higher Learning |
| University of North Carolina at Chapel Hill | New Directions Fellowships | 03/19/10 | $221,000 | Chapel Hill, NC, United States | Higher Learning |
