| Yale University | Yale Baroque Opera Project | 03/19/10 | $525,000 | New Haven, CT, United States | Higher Learning |
| Willamette University | Liberal Arts Research Collaborative | 03/19/10 | $460,000 | Salem, OR, United States | Higher Learning |
| College of the Holy Cross | Mid-Career President: Center for Teaching and Learning | 03/19/10 | $150,000 | Worcester, MA, United States | Higher Learning |
| Brown University | Mellon Mays Undergraduate Fellowship Program - Additional Years Support | 03/19/10 | $123,800 | Providence, RI, United States | Higher Learning |
| Harvard University | Mellon Mays Undergraduate Fellowship Program - Additional Years Support | 03/19/10 | $123,800 | Cambridge, MA, United States | Higher Learning |
| University of Southern California | Mellon Mays Undergraduate Fellowship Program - Additional Years Support | 03/19/10 | $123,800 | Los Angeles, CA, United States | Higher Learning |
| University of California at Berkeley | Mellon Mays Undergraduate Fellowship Program - 10% Increase | 03/19/10 | $22,500 | Berkeley, CA, United States | Higher Learning |
| Stellenbosch University | Postgraduate Program | 03/19/10 | $800,000 | Matieland, South Africa | International Higher Education and Strategic Projects |
| University of Cape Town | Senior Research Scholars Program | 03/19/10 | $750,000 | Cape Town, South Africa | International Higher Education and Strategic Projects |
| King’s College London | Prototype Prosopography of Medieval Physicians | 03/19/10 | $50,000 | London, United Kingdom | Public Knowledge |
| Winthrop Group, Inc. | Gutenberg-e Publishing Project - Phase II | 03/19/10 | $198,000 | New York, NY, United States | Public Knowledge |
| American Friends of the National Gallery London, Inc. | Mellon Research Fellow | 03/01/10 | $6,237 | New York, NY, United States | Arts and Culture |
| Rhodes College | Public and Digital Arts | 02/22/10 | $50,000 | Memphis, TN, United States | Higher Learning |
| Walker Art Center, Inc. | Assessment of Cunningham Production Archive | 02/22/10 | $15,000 | Minneapolis, MN, United States | Arts and Culture |
| Dance Theatre of Harlem, Inc. | Artistic and Organizational Development | 02/22/10 | $100,000 | New York, NY, United States | Arts and Culture |
| Beethoven, A Non-profit Corporation | Classical Radio Collaboration Exploration | 02/22/10 | $29,000 | Seattle, WA, United States | Arts and Culture |
| College of the Holy Cross | Summer Research Fellowships | 02/22/10 | $67,630 | Worcester, MA, United States | Higher Learning |
| Smith College | New Directions Post-Fellowship Award | 02/22/10 | $50,000 | Northampton, MA, United States | Higher Learning |
| University of Southern California | Archaeology Research Enabled by Advanced Photon Source | 02/16/10 | $24,000 | Los Angeles, CA, United States | Public Knowledge |
| Nikolais Louis Foundation for Dance, Inc. | Nikolais Centennial Celebration - Joyce Theater Season | 02/01/10 | $40,000 | New York, NY, United States | Arts and Culture |
| University of Wyoming | Plants Initiative | 02/01/10 | $29,000 | Laramie, WY, United States | Past Programs |
| 7 Stages, Inc. | Bernard-Marie KoltèsSymposium | 02/01/10 | $30,000 | Atlanta, GA, United States | Arts and Culture |
| Louisiana State University and Agricultural and Mechanical College | Electronic Journal | 02/01/10 | $50,800 | Baton Rouge, LA, United States | Public Knowledge |
| Harvard University | New Directions Post-Fellowship Award [Blair] | 02/01/10 | $50,000 | Cambridge, MA, United States | Higher Learning |
| Yale University | New Directions Post-Fellowship Award [Lu] | 02/01/10 | $50,000 | New Haven, CT, United States | Higher Learning |
