| University of Chicago | Distinguished Achievement Award [Lear] | 03/19/10 | $1,500,000 | Chicago, IL, United States | Higher Learning |
| Williams College | New Directions Fellowships [Foias] | 03/19/10 | $208,000 | Williamstown, MA, United States | Higher Learning |
| New York University | Institute of Fine Arts Review | 03/19/10 | $1,523,000 | New York, NY, United States | Higher Learning |
| Amherst College | Faculty-Student Research | 03/19/10 | $200,000 | Amherst, MA, United States | Higher Learning |
| St. John’s College (Annapolis) | Senior President: Biology Curriculum Redesign | 03/19/10 | $250,000 | Annapolis, MD, United States | Higher Learning |
| College of the Holy Cross | Mid-Career President: Center for Teaching and Learning | 03/19/10 | $150,000 | Worcester, MA, United States | Higher Learning |
| Duke University | Mellon Mays Undergraduate Fellowship Program - Additional Years Support | 03/19/10 | $123,800 | Durham, NC, United States | Higher Learning |
| University of Cape Town | Senior Research Scholars Program | 03/19/10 | $750,000 | Cape Town, South Africa | International Higher Education and Strategic Projects |
| University of the Witwatersrand | Postdoctoral Fellowships | 03/19/10 | $350,000 | Johannesburg, South Africa | International Higher Education and Strategic Projects |
| University of Leeds | The Cambridge Edition of Ben Jonson Online | 03/19/10 | $246,000 | Leeds, United Kingdom | Public Knowledge |
| New York University | Moving Image Preservation | 03/19/10 | $523,000 | New York, NY, United States | Public Knowledge |
| American Friends of the National Gallery London, Inc. | Mellon Research Fellow | 03/01/10 | $6,237 | New York, NY, United States | Arts and Culture |
| Smith College | New Directions Post-Fellowship Award | 02/22/10 | $50,000 | Northampton, MA, United States | Higher Learning |
| Beethoven, A Non-profit Corporation | Classical Radio Collaboration Exploration | 02/22/10 | $29,000 | Seattle, WA, United States | Arts and Culture |
| Walker Art Center, Inc. | Assessment of Cunningham Production Archive | 02/22/10 | $15,000 | Minneapolis, MN, United States | Arts and Culture |
| Dance Theatre of Harlem, Inc. | Artistic and Organizational Development | 02/22/10 | $100,000 | New York, NY, United States | Arts and Culture |
| College of the Holy Cross | Summer Research Fellowships | 02/22/10 | $67,630 | Worcester, MA, United States | Higher Learning |
| Rhodes College | Public and Digital Arts | 02/22/10 | $50,000 | Memphis, TN, United States | Higher Learning |
| University of Southern California | Archaeology Research Enabled by Advanced Photon Source | 02/16/10 | $24,000 | Los Angeles, CA, United States | Public Knowledge |
| Sarah Lawrence College | Environmental Studies | 02/01/10 | $95,900 | Bronxville, NY, United States | Higher Learning |
| Louisiana State University and Agricultural and Mechanical College | Electronic Journal | 02/01/10 | $50,800 | Baton Rouge, LA, United States | Public Knowledge |
| Yale University | New Directions Post-Fellowship Award [Lu] | 02/01/10 | $50,000 | New Haven, CT, United States | Higher Learning |
| University of Wyoming | Plants Initiative | 02/01/10 | $29,000 | Laramie, WY, United States | Past Programs |
| Pomona College | New Directions Post-Fellowship Award [Williams] | 02/01/10 | $50,000 | Claremont, CA, United States | Higher Learning |
| Nikolais Louis Foundation for Dance, Inc. | Nikolais Centennial Celebration - Joyce Theater Season | 02/01/10 | $40,000 | New York, NY, United States | Arts and Culture |
