| Yale University | Consortium for Language Teaching and Learning - Part 1 | 03/19/87 | $850,000 | New Haven, CT, United States | Higher Learning |
| University of Illinois at Chicago | Crossing Latinidades: Building Latino/a Studies at R-1 Hispanic-Serving Institutions | 07/21/20 | $150,000 | Chicago, IL, United States | Higher Learning |
| University of Notre Dame | Arts and Letters 5+1 Graduate Program | 06/13/16 | $1,500,000 | Notre Dame, IN, United States | Higher Learning |
| Indiana University | Kuali - Open Library Environment Project 1 | 12/10/09 | $2,380,000 | Bloomington, IN, United States | Higher Learning |
| Yale University | Consortium for Language Teaching and Learning - Part 1 | 10/05/83 | $32,000 | New Haven, CT, United States | Higher Learning |
| University of Hartford | EEP - Krakow Managment Education Project [#1] | 06/10/91 | $158,000 | West Hartford, CT, United States | Other |
| Northwestern University | Mellon Mays Undergraduate Fellowship Program - 10% Increase | 03/19/10 | $22,500 | Evanston, IL, United States | Higher Learning |
| Whittier College | Mellon Mays Undergraduate Fellowship Program - 10% Increase | 03/19/10 | $22,500 | Whittier, CA, United States | Higher Learning |
| Grinnell College | Mellon Mays Undergraduate Fellowship Program - 10% Increase | 03/19/10 | $22,500 | Grinnell, IA, United States | Higher Learning |
| University of the Witwatersrand | Mellon Mays Undergraduate Fellowship Program - 10% Increase | 03/19/10 | $22,500 | Johannesburg, South Africa | Higher Learning |
| Connecticut College | Mellon Mays Undergraduate Fellowship Program - 10% Increase | 03/19/10 | $22,500 | New London, CT, United States | Higher Learning |
| University of the Western Cape | Mellon Mays Undergraduate Fellowship Program - 10% Increase | 03/19/10 | $22,500 | Bellville, South Africa | Higher Learning |
| Harvard University | Graduate Education - 10 University Study | 03/13/95 | $650,000 | Cambridge, MA, United States | Higher Learning |
| University of California at Los Angeles | Mellon Mays Undergraduate Fellowship Program - 10% Increase | 03/19/10 | $22,500 | Los Angeles, CA, United States | Higher Learning |
| University of California at Berkeley | Mellon Mays Undergraduate Fellowship Program - 10% Increase | 03/19/10 | $22,500 | Berkeley, CA, United States | Higher Learning |
| Burlington Magazine Foundation, Inc. | 100-Year Index | 10/01/04 | $750,000 | London, United Kingdom | Public Knowledge |
| West Virginia University | 100 Days in Appalachia | 06/06/19 | $250,000 | Morgantown, WV, United States | Higher Learning |
| University of North Carolina at Chapel Hill | Rite of Spring 100 | 09/20/10 | $45,000 | Chapel Hill, NC, United States | Arts and Culture |
| Harvard University | Atlantic History Seminar - Part 11 | 05/09/05 | $35,000 | Cambridge, MA, United States | Higher Learning |
| InterRelations Collaborative, Inc. | Commemorative - Fifth Anniversary of September 11, 2001 | 04/17/06 | $10,000 | Hamden, CT, United States | Other |
| Harvard University | The Democracy Project: A National Initiative to Improve Civics Education in K-12 Schools | 03/06/19 | $1,000,000 | Cambridge, MA, United States | Other |
| Carnegie Hall Society, Inc. | 125 Commissions Project and NYO2 | 03/10/16 | $1,750,000 | New York, NY, United States | Arts and Culture |
| University of Toronto | Sawyer Seminar: 'Religious Materiality in the Indian Ocean World, 1300 - 1800' | 06/05/14 | $175,000 | Toronto, Ontario, Canada | Higher Learning |
| University of Wisconsin at Madison | Visualizing English Print from c.1470 to 1800 | 06/03/11 | $411,000 | Madison, WI, United States | Public Knowledge |
| University of Wisconsin at Madison | Visualizing English Print from c 1470 to 1800 - Phase II | 12/06/12 | $925,000 | Madison, WI, United States | Public Knowledge |
